Ramelteon

Definition

A synthetic melatonin analogue with hypnotic and circadian rhythm-modulating activities. Ramelteon binds to and activates melatonin receptors 1 and 2 in the suprachiasmatic nucleus (SCN) of the brain, thereby promoting the onset of sleep. Unlike the nonbenzodiazepine sedative hypnotics zolpidem and zaleplon, this agent does not activate GABA receptors and, so, produces no GABA receptor-mediated anxiolytic, myorelaxant, and amnesic effects.

Also known as RAMELTEON, Rozerem, TAK-375 — per NCIT

Also identified as

• ATC N05CH02 per RXNORM
• NCIT NCIT:C66504 per NCIT
• SCTID 419588002 per RXNORM
• SCTID 419878007 per RXNORM
• UNII 901AS54I69 per RXNORM

Indications