Lubiprostone
Lubiprostone
Definition
A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements.
Also known as Amitiza, LUBIPROSTONE — per NCIT
Also identified as
- ATC A06AX03 per RXNORM
- NCIT NCIT:C66040 per NCIT
- SCTID 420304008 per RXNORM
- SCTID 421856003 per RXNORM
- UNII 7662KG2R6K per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Constipation disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Irritable bowel syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.