Digoxin
Digoxin
Definition
A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)
Also known as 12beta-Hydroxydigitoxin, 3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosid, Cardiogoxin, Digoxigenin-tridigitoxosid, DIGOXIN, Lanoxin — per NCIT
Also identified as
- ATC C01AA per NCIT
- NCIT NCIT:C28990 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Heart failure | may prevent | MEDRT · Public domain (U.S. Government work) |
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Atrial fibrillation | may treat | MEDRT · Public domain (U.S. Government work) |
| Atrial flutter | may treat | MEDRT · Public domain (U.S. Government work) |
| Heart failure | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.