Lacosamide

ATC Code N03AX18

Lacosamide

Definition

A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.

Also known as (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide, ADD 234037, Erlosamide, Harkoseride, LACOSAMIDE, SPM 927, Vimpat — per NCIT

Also identified as

Indications

Disease Relation Source
Epilepsy with generalized tonic-clonic seizures may treat MEDRT · Public domain (U.S. Government work)
Focal epilepsy may treat MEDRT · Public domain (U.S. Government work)
Lennox-Gastaut syndrome may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Brain may treat a disease of this organ DERIVED · CC BY 4.0
Central nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Nervous system may treat a disease of this organ DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.