Temsirolimus

Definition

An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.

Also known as 42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin, CCI 779, CCI-779, CCI-779 Rapamycin Analog, CCI779, Cell Cycle Inhibitor 779, Rapamycin Analog, Rapamycin Analog CCI-779, TEMSIROLIMUS, Torisel — per NCIT

Also identified as

• ATC L01EG01 per RXNORM
• NCIT NCIT:C1844 per NCIT
• SCTID 427153004 per RXNORM
• SCTID 427299005 per RXNORM
• UNII 624KN6GM2T per RXNORM

Indications