Pazopanib

Definition

A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

Also known as Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, GW786034, PAZOPANIB — per NCIT

Also identified as

• ATC L01EX03 per RXNORM
• NCIT NCIT:C74547 per NCIT
• SCTID 443763005 per RXNORM
• SCTID 443764004 per RXNORM
• UNII 7RN5DR86CK per RXNORM

Indications