Plerixafor

Definition

A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.

NCIT:C1777 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane, AMD 3100, AMD-3100, AMD3100, JM-3100, Mozobil, PLERIXAFOR, SDZ SID 791 — per NCIT

Also identified as

ATC L03AX16 per RXNORM
NCIT NCIT:C1777 per NCIT
SCTID 442206008 per RXNORM
SCTID 442264009 per RXNORM
UNII S915P5499N per RXNORM

Indications

Disease	Relation	Source
Multiple myeloma	may treat	MEDRT · Public domain (U.S. Government work)
Non-Hodgkin lymphoma	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Lymphoid system	may treat a disease of this organ	DERIVED · CC BY 4.0

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.