Glioblastoma

Glioblastoma

Definition

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

Also known as GBM, GBM (glioblastoma), glioblastoma, glioblastoma (disease), glioblastoma multiforme, glioblastoma multiforme (disease), grade IV astrocytic neoplasm, grade IV astrocytic tumor, grade IV astrocytic tumour, grade IV astrocytoma, spongioblastoma multiforme, WHO grade IV glioma — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Central nervous system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Central nervous system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Nervous system Disease Has Associated Anatomic Site NCIT · CC BY 4.0

Drugs indicated

Drug Relation Source
Bevacizumab may treat MEDRT · Public domain (U.S. Government work)
Carmustine may treat MEDRT · Public domain (U.S. Government work)
Temozolomide may treat MEDRT · Public domain (U.S. Government work)