Carmustine
Carmustine
Definition
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
Also known as 1,3-Bis(2-chloroethyl)-1-nitrosourea, 1,3-Bis(beta-chloroethyl)-1-nitrosourea, BCNU, Becenum, Becenun, BiCNU, Bis-Chloronitrosourea, Bis(chloroethyl) Nitrosourea, Carmubris, Carmustin, CARMUSTINE, Carmustinum, FDA 0345, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Nitrourean, Nitrumon, NSC 409962, NSC409962, SK 27702, SRI 1720, WR 139021, WR-139021, WR139021 — per NCIT
Also identified as
- ATC L01AD01 per RXNORM
- NCIT NCIT:C349 per NCIT
- SCTID 387281007 per RXNORM
- SCTID 51326002 per RXNORM
- SCTID 786790001 per RXNORM
- UNII U68WG3173Y per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Brain cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Colonic neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Ependymoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Glioblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Lung neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Medulloblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Multiple myeloma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cerebellum | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.