Malignant hyperthermia of anesthesia

Definition

A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.

Also known as anaesthesia related hyperthermia, hyperthermia of anaesthesia, hyperthermia of anesthesia, malignant hyperpyrexia, malignant hyperpyrexia due to anaesthesia, malignant hyperthermia, malignant hyperthermia of anesthesia, malignant hyperthermia syndrome — per MONDO

Also identified as

• DOID 8545 per MONDO
• ICD9 995.86 per MONDO
• MESH D008305 per MONDO
• NCIT C84869 per MONDO
• Orphanet 423 per MONDO
• SCTID 405501007 per MONDO
• UMLS C0024591 per MONDO

Drugs indicated