Dantrolene
ATC Code
M03CA01
Dantrolene
Definition
A hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction.
Also known as DANTROLENE — per NCIT
Also identified as
- ATC M03CA01 per RXNORM
- NCIT NCIT:C61697 per NCIT
- SCTID 372819007 per RXNORM
- SCTID 69107004 per RXNORM
- UNII F64QU97QCR per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cerebral infarction | may treat | MEDRT · Public domain (U.S. Government work) |
| Cerebral palsy | may treat | MEDRT · Public domain (U.S. Government work) |
| Malignant hyperthermia of anesthesia | may treat | MEDRT · Public domain (U.S. Government work) |
| Multiple sclerosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Neuroleptic malignant syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Spinal cord injury | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.