Juvenile Paget disease

Juvenile Paget disease

Definition

Juvenile Paget disease is a very rare form of Paget disease of the bone characterized by a general increase in bone turnover with increased bone resorption and deposition, resulting in cortical and trabecular thickening, and clinically presenting as progressive skeletal deformities, growth impairment, fractures, vertebral collapse, skull enlargement and sensorineural hearing loss.

Also known as familial hyperphosphatasia, familial osteoectasia, Hereditary Hyperphosphatasia, hyperostosis corticalis deformans juvenilis, JPG, juvenile Paget disease, juvenile Paget's disease — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Bone element Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Bone element Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Connective tissue Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Musculoskeletal system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Musculoskeletal system Disease Has Primary Anatomic Site NCIT · CC BY 4.0