Acute promyelocytic leukemia

Definition

An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.

Also known as acute myeloblastic leukaemia 3, acute myeloblastic leukemia 3, acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variants, acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants, acute promyelocytic leukaemia with PML-rara, acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-rara, acute promyelocytic leukaemia with t(15;17)(q22;q12); PML/rara, acute promyelocytic leukemia, acute promyelocytic leukemia with PML-rara, acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara, acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara, AML M3, AML with t(15;17)(q22;q12), AML with t(15;17)(q22;q12);(PML/RARalpha) and variants, APL, APML, APML - acute promyelocytic leukaemia, APML - acute promyelocytic leukemia, FAB M3, leukemia, acute promyelocytic, somatic, promyelocytic leukaemia, promyelocytic leukemia — per MONDO

Also identified as

• DOID 0060318 per MONDO
• DOID 0081081 per MONDO
• ICD10CM C92.4 per MONDO
• MESH D015473 per MONDO
• NCIT C3182 per MONDO
• OMIM 612376 per MONDO
• Orphanet 520 per MONDO
• SCTID 110004001 per MONDO
• UMLS C0023487 per MONDO

Affected Organs

Drugs indicated