Arsenic Trioxide
Arsenic Trioxide
Definition
A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)
Also known as Arsenic (III) Oxide, Arsenic Sesquioxide, ARSENIC TRIOXIDE, Arsenous Acid, Arsenous Acid Anhydride, Arsenous Oxide, ATO, Trisenox, White Arsenic — per NCIT
Also identified as
- ATC L01XX27 per RXNORM
- NCIT NCIT:C1005 per NCIT
- SCTID 400907001 per RXNORM
- SCTID 72251000 per RXNORM
- UNII S7V92P67HO per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acute promyelocytic leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.