Fidaxomicin

Definition

A narrow-spectrum, 18-membered macrolide antibiotic isolated from the actinomycete Dactylosporangium aurantiacum subsp. hamdenensis with potential antibacterial activity. Although the exact mechanism of action has yet to be fully elucidated, fidaxomicin may bind to and inhibit bacterial DNA-dependent RNA polymerase, thereby inhibiting the initiation of bacterial RNA synthesis. When orally administered, this agent is minimally absorbed into the systemic circulation, acting locally in the gastrointestinal tract. Fidaxomicin appears to be active against pathogenic Gram-positive bacteria, such as clostridia, enterococci, and staphylococci, but does not appear to be active against other beneficial intestinal bacteria.

NCIT:C66979 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as Clostomicin B1, Dificid, Difimicin, FIDAXOMICIN, Lipiarmycin A3, OPT-80, PAR-101, Tiacumicin B — per NCIT

Also identified as

ATC A07AA12 per RXNORM
NCIT NCIT:C66979 per NCIT
SCTID 703664004 per RXNORM
SCTID 703665003 per RXNORM
UNII Z5N076G8YQ per RXNORM

Indications

Disease	Relation	Source
Clostridium difficile colitis	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Alimentary part of gastrointestinal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Colon	may treat a disease of this organ	DERIVED · CC BY 4.0
Intestine	may treat a disease of this organ	DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.