Pirfenidone
Pirfenidone
Definition
An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04)
Also known as PIRFENIDONE — per NCIT
Also identified as
- ATC L04AX05 per RXNORM
- NCIT NCIT:C2635 per NCIT
- SCTID 438240001 per RXNORM
- SCTID 439581000 per RXNORM
- UNII D7NLD2JX7U per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Pulmonary fibrosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.