Trabectedin
Trabectedin
Definition
A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinata with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks and blocks the cell cycle in the G2 phase.
Also known as Ecteinascidin, Ecteinascidin 743, ET 743, ET-743, ET743, TRABECTEDIN, Yondelis — per NCIT
Also identified as
- ATC L01CX01 per RXNORM
- NCIT NCIT:C1691 per NCIT
- SCTID 432214004 per RXNORM
- SCTID 433127001 per RXNORM
- UNII ID0YZQ2TCP per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Leiomyosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Liposarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Smooth muscle | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.