Amifampridine

Definition

An organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.

NCIT:C82687 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 3,4-DAP, 3,4-Diaminopyridine, 3,4-Pyridinediamine, 4,5-Diaminopyridine, AMIFAMPRIDINE, Firdapse, Pyridine, 3,4-Diamino-, SC10 — per NCIT

Also identified as

ATC N07XX05 per RXNORM
NCIT NCIT:C82687 per NCIT
SCTID 422654000 per RXNORM
SCTID 782983000 per RXNORM
UNII RU4S6E2G0J per RXNORM

Indications

Disease	Relation	Source
Lambert-Eaton myasthenic syndrome	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Musculature	may treat a disease of this organ	DERIVED · CC BY 4.0
Musculoskeletal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0
Peripheral nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0

4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.