Lurbinectedin
ATC Code
L01XX69
Lurbinectedin
Definition
A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.
Also known as LURBINECTEDIN, PM 01183, PM-01183, PM01183, Zepzelca — per NCIT
Also identified as
- ATC L01XX69 per RXNORM
- NCIT NCIT:C82382 per NCIT
- SCTID 879925002 per RXNORM
- SCTID 879932006 per RXNORM
- UNII 2CN60TN6ZS per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bronchi | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocrine gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.