Efavirenz

Definition

A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.

Also known as DMP-266, EFAVIRENZ, L743726, MK-0831, Sustiva — per NCIT

Also identified as

• ATC J05AG per NCIT
• ATC J05AR per NCIT
• NCIT NCIT:C29027 per NCIT

Indications