Allopurinol
Allopurinol
Definition
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)
Also known as 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one, 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 1H-Pyrazolo[3,4-d]pyrimidin-4-ol, 4-Hydroxypyrazolo[3,4-d]pyrimidine, 4'-HPP, ALLOPURINOL, Lopurin, Sigapurol, Zurinol — per NCIT
Also identified as
- ATC M04AA per NCIT
- NCIT NCIT:C224 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Gout | may prevent | MEDRT · Public domain (U.S. Government work) |
| Tumor lysis syndrome | may prevent | MEDRT · Public domain (U.S. Government work) |
| Gout | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.