Trimethoprim
Trimethoprim
Definition
A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid. The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)
Also known as 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, Proloprim, TRIMETHOPRIM, Trimpex — per NCIT
Also identified as
- ATC J01EA per NCIT
- ATC J01EE per NCIT
- NCIT NCIT:C908 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Bronchitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Klebsiella infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Pneumocystosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Proteus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Toxoplasmosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.