Alprostadil
Alprostadil
Definition
The naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.
Also known as (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid, ALPROSTADIL, Caverject, MUSE, Muse (intraurethral alprostadil suppository), PGE1, Prostaglandin E1 — per NCIT
Also identified as
- ATC C01EA01 per RXNORM
- ATC G04BE01 per RXNORM
- NCIT NCIT:C28816 per NCIT
- SCTID 109119001 per RXNORM
- SCTID 48988008 per RXNORM
- UNII F5TD010360 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Aorta coarctation | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypoplastic left heart syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Patent ductus arteriosus | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary hypertension | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary valve stenosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Tetralogy of fallot | may treat | MEDRT · Public domain (U.S. Government work) |
| Tricuspid atresia | may treat | MEDRT · Public domain (U.S. Government work) |
| Vasculogenic impotence | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.