Amantadine
Amantadine
Definition
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
Also known as AMANTADINE — per NCIT
Also identified as
- ATC N04BB01 per RXNORM
- NCIT NCIT:C61632 per NCIT
- SCTID 372763006 per RXNORM
- SCTID 51361008 per RXNORM
- UNII BF4C9Z1J53 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Influenza | may prevent | MEDRT · Public domain (U.S. Government work) |
| Drug-induced akathisia | may treat | MEDRT · Public domain (U.S. Government work) |
| Drug-induced dyskinesia | may treat | MEDRT · Public domain (U.S. Government work) |
| Influenza | may treat | MEDRT · Public domain (U.S. Government work) |
| Parkinson's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Secondary Parkinson disease | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.