Aminophylline
Aminophylline
Definition
A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.
Also known as 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1), AMINOPHYLLINE, Ammophyllin, Phyllocontin, Theophyline Ethylenediamine, Truphylline — per NCIT
Also identified as
- ATC R03DA05 per RXNORM
- NCIT NCIT:C47393 per NCIT
- SCTID 373508009 per RXNORM
- SCTID 55867006 per RXNORM
- UNII 27Y3KJK423 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Asthma | may treat | MEDRT · Public domain (U.S. Government work) |
| Bronchitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary emphysema | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.