Bacitracin
Bacitracin
Definition
A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.
Also known as BACITRACIN — per NCIT
Also identified as
- ATC D06AX05 per RXNORM
- ATC J01XX10 per RXNORM
- ATC R02AB04 per RXNORM
- ATC S01AA32 per RXNORM
- NCIT NCIT:C295 per NCIT
- SCTID 370330005 per RXNORM
- SCTID 5220000 per RXNORM
- UNII 58H6RWO52I per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Skin disease caused by bacterial infection | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bacterial conjunctivitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Clostridium difficile colitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Empyema | may treat | MEDRT · Public domain (U.S. Government work) |
| Pneumonia | may treat | MEDRT · Public domain (U.S. Government work) |
| Skin disease caused by bacterial infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Colon | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Conjunctiva | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ocular adnexa | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
9 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.