Baclofen

Definition

A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04)

NCIT:C28858 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 4-Amino-3-(4-chlorophenyl)-butanoic Acid, BA34647, BACLOFEN, beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid, Gablofen, Kemstro, Lioresal — per NCIT

Also identified as

ATC M03BX01 per RXNORM
NCIT NCIT:C28858 per NCIT
SCTID 387342009 per RXNORM
SCTID 6102009 per RXNORM
UNII H789N3FKE8 per RXNORM

Indications

Disease	Relation	Source
Acute transverse myelitis	may treat	MEDRT · Public domain (U.S. Government work)
Cerebral palsy	may treat	MEDRT · Public domain (U.S. Government work)
Huntington's disease	may treat	MEDRT · Public domain (U.S. Government work)
Multiple sclerosis	may treat	MEDRT · Public domain (U.S. Government work)
Spinal cord injury	may treat	MEDRT · Public domain (U.S. Government work)
Spinal cord ischemia	may treat	MEDRT · Public domain (U.S. Government work)
Spinal cord neoplasm	may treat	MEDRT · Public domain (U.S. Government work)
Spondylolysis	may treat	MEDRT · Public domain (U.S. Government work)
Trigeminal neuralgia	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Bone element	may treat a disease of this organ	DERIVED · CC BY 4.0
Central nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0
Musculoskeletal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Nervous system	may treat a disease of this organ	DERIVED · CC BY 4.0

4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.