Calcitriol
Calcitriol
Definition
A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04)
Also known as (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 1,25-DHCC, 1,25-Dihydroxycholecalciferol, 1,25-Dihydroxycholecaliferol, 1,25(OH)2-D3, Calcijex, CALCITRIOL, Rocaltrol — per NCIT
Also identified as
- ATC A11CC04 per RXNORM
- ATC D05AX03 per RXNORM
- NCIT NCIT:C330 per NCIT
- SCTID 259333003 per RXNORM
- SCTID 68206008 per RXNORM
- UNII 5RWP08OQ36 per RXNORM
- UNII FXC9231JVH per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Vitamin D deficiency | may prevent | MEDRT · Public domain (U.S. Government work) |
| Hyperparathyroidism | may treat | MEDRT · Public domain (U.S. Government work) |
| Psoriasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rickets | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Parathyroid glands | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.