Chloramphenicol
Chloramphenicol
Definition
A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.
Also known as [R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide, CHLORAMPHENICOL — per NCIT
Also identified as
- ATC D06AX02 per RXNORM
- ATC D10AF03 per RXNORM
- ATC G01AA05 per RXNORM
- ATC J01BA01 per RXNORM
- ATC S01AA01 per RXNORM
- ATC S02AA01 per RXNORM
- ATC S03AA08 per RXNORM
- NCIT NCIT:C363 per NCIT
- SCTID 372777009 per RXNORM
- SCTID 57191001 per RXNORM
- UNII 66974FR9Q1 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacteroides infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Haemophilus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Meningococcal meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Otitis externa | may treat | MEDRT · Public domain (U.S. Government work) |
| Rickettsiosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Salmonellosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ear | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| External ear | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.