Dacarbazine
Dacarbazine
Definition
A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
Also known as 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, DACARBAZINE, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007 — per NCIT
Also identified as
- ATC L01AX04 per RXNORM
- NCIT NCIT:C411 per NCIT
- SCTID 387441003 per RXNORM
- SCTID 77750008 per RXNORM
- UNII 7GR28W0FJI per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Fibrosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Neuroblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Pancreatic endocrine carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Rhabdomyosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocrine gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Pancreas | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Striated muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
7 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.