Dactinomycin
Dactinomycin
Definition
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
Also known as 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3, Actinomycin A IV, Actinomycin C1, ACTINOMYCIN D, Actinomycin I1, Actinomycin IV, Actinomycin X 1, Actinomycin-[thr-val-pro-sar-meval], Cosmegen, DACT, DACTINOMYCIN, Dactinomycine, Lyovac Cosmegen, Meractinomycin — per NCIT
Also identified as
- ATC L01DA01 per RXNORM
- NCIT NCIT:C412 per NCIT
- SCTID 387353003 per RXNORM
- SCTID 64127001 per RXNORM
- UNII 1CC1JFE158 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Choriocarcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ewing sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Kaposi's sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Neuroblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Retinoblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Rhabdomyosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Testicular cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Uterine cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Wilms tumor | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Blood vessel | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Retina | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Striated muscle tissue | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.