Choriocarcinoma

Definition

An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.

Also known as chorioblastoma, choriocarcinoma, choriocarcinoma (disease), choriocarcinoma, malignant, chorioepithelioma, chorion carcinoma, chorionic carcinoma — per MONDO

Also identified as

• DOID 3594 per MONDO
• MESH D002822 per MONDO
• NCIT C2948 per MONDO
• SCTID 188188009 per MONDO
• UMLS C0008497 per MONDO

Drugs indicated