Chlorambucil

Definition

An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)

Also known as .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid, .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid, .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid, 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid, Alti-chlorambucil, Ambochlorin, Amboclorin, Aminochlorambucil, Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI), Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-, butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl), Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-, CB 1348, CB-1348, CHL, CHLORAMBUCIL, Chlorambucilum, Chloraminophen, Chloraminophene, Chlorbutin, Chlorbutine, chlorbutinum, Chloroambucil, Chlorobutin, Chlorobutine, Ecloril, Elcoril, gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid, gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid, Leukeran, Leukersan, Leukoran, Linfolizin, Linfolysin, Lympholysin, N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid, p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid, p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid, p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid, Phenylbutyric acid nitrogen mustard, WR-139013 — per NCIT

Also identified as

• ATC L01AA02 per RXNORM
• NCIT NCIT:C362 per NCIT
• SCTID 387249003 per RXNORM
• SCTID 46009007 per RXNORM
• UNII 18D0SL7309 per RXNORM

Indications

Organ Effects

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.