Bleomycin
Bleomycin
Definition
A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.
Also known as BLEO, BLEOMYCIN, BLM — per NCIT
Also identified as
- ATC L01DC per NCIT
- NCIT NCIT:C313 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Choriocarcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Squamous cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Teratocarcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Testicular cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.