Vinblastine
Vinblastine
Definition
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
Also known as VINBLASTINE, Vincaleucoblastine, VLB — per NCIT
Also identified as
- ATC L01CA per NCIT
- NCIT NCIT:C930 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Choriocarcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Histiocytosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Kaposi's sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Kidney cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Lung neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Mycosis fungoides | may treat | MEDRT · Public domain (U.S. Government work) |
| Testicular cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Blood vessel | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.