Methotrexate
Methotrexate
Definition
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
Also known as 4-Amino-10-methylfolic Acid, 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Jylamvo, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, METHOTREXATE, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039 — per NCIT
Also identified as
- ATC L01BA per NCIT
- ATC L04AX per NCIT
- NCIT NCIT:C642 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Choriocarcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Crohn's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastric neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Hydatidiform mole | may treat | MEDRT · Public domain (U.S. Government work) |
| Juvenile idiopathic arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Lung neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Mycosis fungoides | may treat | MEDRT · Public domain (U.S. Government work) |
| Osteosarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Psoriasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Testicular cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Placenta | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
9 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.