Ifosfamide
Ifosfamide
Definition
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)
Also known as 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, IFOSFAMIDE, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942 — per NCIT
Also identified as
- ATC L01AA06 per RXNORM
- NCIT NCIT:C564 per NCIT
- SCTID 108757000 per RXNORM
- SCTID 386904003 per RXNORM
- UNII UM20QQM95Y per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| B-cell chronic lymphocytic leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastric neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Lung neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Pancreatic neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Testicular cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.