Isoniazid

Definition

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)

Also known as ISONIAZID, Isonicotinic Acid Hydrazide, Isonicotinyl Hydrazine — per NCIT

Also identified as

• ATC J04AC01 per RXNORM
• NCIT NCIT:C600 per NCIT
• SCTID 387472004 per RXNORM
• SCTID 81335000 per RXNORM
• UNII V83O1VOZ8L per RXNORM

Indications