Tuberculosis

Definition

A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.

Also known as tuberculosis disease — per MONDO

Also identified as

• DOID 399 per MONDO
• ICD10CM A15-A19 per MONDO
• ICD9 017.90 per MONDO
• ICD9 017.92 per MONDO
• ICD9 017.94 per MONDO
• ICD9 017.96 per MONDO
• MESH D014376 per MONDO
• NCIT C3423 per MONDO
• Orphanet 3389 per MONDO
• SCTID 56717001 per MONDO
• UMLS C0041296 per MONDO

Drugs indicated