Cycloserine

Definition

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

Also known as (+)-4-Amino-3-isoxazolidinone, 3-Isoxazolidinone, 4-amino-, d-, CYCLOSERINE, D-Cycloserine, Oxamycin, Seromycin, Tisomycin — per NCIT

Also identified as

• ATC J04AB01 per RXNORM
• NCIT NCIT:C47466 per NCIT
• SCTID 387282000 per RXNORM
• SCTID 51334008 per RXNORM
• UNII 95IK5KI84Z per RXNORM

Indications