Naloxone
Naloxone
Definition
A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.
Also known as (-)-Naloxone, NALOXONE — per NCIT
Also identified as
- ATC A06AH04 per RXNORM
- ATC V03AB15 per RXNORM
- NCIT NCIT:C62054 per NCIT
- SCTID 372890007 per RXNORM
- SCTID 89018006 per RXNORM
- UNII 36B82AMQ7N per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Opiate dependence | may treat | MEDRT · Public domain (U.S. Government work) |
| Toxic shock syndrome | may treat | MEDRT · Public domain (U.S. Government work) |