Toxic shock syndrome

Definition

A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.

Also known as bacterial toxic-shock syndrome, bacterial TSS, shock syndrome (TSS), toxic, syndrome (TSS), toxic shock, toxic shock syndrome, toxic shock syndrome, (TSS), TSS, TSS, toxic shock syndrome — per MONDO

Also identified as

• DOID 14115 per MONDO
• ICD10CM A48.3 per MONDO
• ICD9 040.82 per MONDO
• MESH D012772 per MONDO
• NCIT C35498 per MONDO
• Orphanet 36234 per MONDO
• SCTID 18504008 per MONDO
• UMLS C0600327 per MONDO

Drugs indicated