Neomycin
Neomycin
Definition
A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.
Also known as NEOMYCIN, Neomycin Complex — per NCIT
Also identified as
- ATC A01AB08 per RXNORM
- ATC A07AA01 per RXNORM
- ATC B05CA09 per RXNORM
- ATC D06AX04 per RXNORM
- ATC J01GB05 per RXNORM
- ATC R02AB01 per RXNORM
- ATC S01AA03 per RXNORM
- ATC S02AA07 per RXNORM
- ATC S03AA01 per RXNORM
- NCIT NCIT:C683 per NCIT
- SCTID 373528008 per RXNORM
- SCTID 73093001 per RXNORM
- UNII I16QD7X297 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial infectious disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Hepatic encephalopathy | may treat | MEDRT · Public domain (U.S. Government work) |
| Skin disease caused by bacterial infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.