Budesonide

ATC Code R03BA02

Budesonide

Definition

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation.

Also known as (RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ Butyraldehyde, Budecort, BUDESONIDE, Butacort, Eltair, Nasocort, Preferid, Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-, Pulmicort, Pulmicort Turbuhaler, Rhinocort — per NCIT

Also identified as

Indications

Disease Relation Source
Asthma may prevent MEDRT · Public domain (U.S. Government work)
Nasal cavity polyp may prevent MEDRT · Public domain (U.S. Government work)
Inflammatory bowel disease may treat MEDRT · Public domain (U.S. Government work)
Perennial allergic rhinitis may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Alimentary part of gastrointestinal system may treat a disease of this organ DERIVED · CC BY 4.0
Craniocervical region may treat a disease of this organ DERIVED · CC BY 4.0
Intestine may treat a disease of this organ DERIVED · CC BY 4.0
Nasal cavity may treat a disease of this organ DERIVED · CC BY 4.0

4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.