Penicillamine
Penicillamine
Definition
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
Also known as .beta.,.beta.-Dimethylcysteine, 3-Mercapto-D-valine, Alpha-amino-beta-methyl-beta-mercaptobutyric Acid, Atamir, Beta-thiovaline, Beta,Beta-dimethylcysteine, Cuprenil, Cuprimine, Cupripen, D-Mercaptovaline, D-Penicillamine, Depamine, Depen, Distamine, Kelatin, Mercaptyl, Metalcaptase, Pendramine, PENICILLAMINE, Perdolat, Sufortan, Trolovol — per NCIT
Also identified as
- ATC M01CC01 per RXNORM
- NCIT NCIT:C729 per NCIT
- SCTID 387235007 per RXNORM
- SCTID 4219002 per RXNORM
- UNII GNN1DV99GX per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cystinuria | may treat | MEDRT · Public domain (U.S. Government work) |
| Lead poisoning | may treat | MEDRT · Public domain (U.S. Government work) |
| Mercury poisoning | may treat | MEDRT · Public domain (U.S. Government work) |
| Primary biliary cholangitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Wilson's disease | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bile ducts | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Liver | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.