Pentamidine
Pentamidine
Definition
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)
Also known as Aerosolized Pentamadine, PENTAMIDINE — per NCIT
Also identified as
- NCIT NCIT:C731 per NCIT
- SCTID 31692006 per RXNORM
- SCTID 372699006 per RXNORM
- UNII 673LC5J4LQ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Pneumocystosis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Pneumocystosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Trypanosomiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Visceral leishmaniasis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.