Perphenazine
Perphenazine
Definition
A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.
Also known as 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol, PERPHENAZINE — per NCIT
Also identified as
- ATC N05AB03 per RXNORM
- NCIT NCIT:C29355 per NCIT
- SCTID 387229007 per RXNORM
- SCTID 41147003 per RXNORM
- UNII FTA7XXY4EZ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Huntington's disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Reye syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Substance withdrawal syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Tourette syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.