Polymyxin B
Polymyxin B
Definition
A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.
Also known as POLYMYXIN B — per NCIT
Also identified as
- ATC A07AA05 per RXNORM
- ATC J01XB02 per RXNORM
- ATC S01AA18 per RXNORM
- ATC S02AA11 per RXNORM
- ATC S03AA03 per RXNORM
- NCIT NCIT:C61894 per NCIT
- SCTID 372824005 per RXNORM
- SCTID 6960003 per RXNORM
- UNII J2VZ07J96K per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial infectious disease with sepsis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Digestive system disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Haemophilus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Klebsiella infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Otitis externa | may treat | MEDRT · Public domain (U.S. Government work) |
| Pseudomonas infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Skin disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary bladder disorder | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ear | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| External ear | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Meninx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.