Streptozocin
Streptozocin
Definition
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)
Also known as 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose, STREPTOZOCIN, Streptozotocin, STZ, U 9889, U-9889, Zanosar — per NCIT
Also identified as
- ATC L01AD04 per RXNORM
- NCIT NCIT:C845 per NCIT
- SCTID 16915004 per RXNORM
- SCTID 404876000 per RXNORM
- UNII 5W494URQ81 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Colorectal neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Pancreatic endocrine carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocrine gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Pancreas | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.