Chloroquine
Chloroquine
Definition
A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.
Also known as CHLOROQUINE — per NCIT
Also identified as
- ATC P01BA per NCIT
- ATC P01BB per NCIT
- NCIT NCIT:C61671 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Malaria | may prevent | MEDRT · Public domain (U.S. Government work) |
| Amebiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Discoid lupus erythematosus | may treat | MEDRT · Public domain (U.S. Government work) |
| Pemphigus | may treat | MEDRT · Public domain (U.S. Government work) |
| Plasmodium falciparum malaria | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Systemic sclerosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.